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ViRBase: a resource for virus-host ncRNA-associated interactions.

Yanhui Li1, Changliang Wang2, Zhengqiang Miao2

  • 1College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China.

Nucleic Acids Research
|October 3, 2014
PubMed
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Diverse non-coding RNAs (ncRNAs) are crucial in viral infections, affecting both viral and host gene expression. ViRBase is a new resource for exploring these complex virus-host ncRNA interactions.

Area of Science:

  • Virology
  • Molecular Biology
  • Bioinformatics

Background:

  • Non-coding RNAs (ncRNAs) play significant roles in regulating gene expression during viral infections.
  • Viruses exploit host ncRNAs, and host ncRNAs can also target viral components to control replication.
  • Understanding these interactions is key to deciphering viral pathogenesis.

Purpose of the Study:

  • To introduce ViRBase, a comprehensive database for virus-host ncRNA interactions.
  • To provide a resource for browsing, visualizing, and analyzing interaction networks in viral infections.
  • To facilitate the discovery of general principles governing these interactions.

Main Methods:

  • Database curation of viral and cellular ncRNA-associated interactions.
  • Integration of data from over 60 viruses and 20 hosts.

Related Experiment Videos

  • Development of query, browsing, and visualization tools for interaction data.

    • Main Results:

    • ViRBase currently documents over 12,000 interactions.
    • The database includes more than 460 ncRNAs and 4400 protein-coding genes.
    • Interactions encompass virus-virus, virus-host, host-virus, and host-host relationships.

    Conclusions:

    • ViRBase serves as a valuable resource for researchers studying viral infections and ncRNA.
    • The database aids in understanding the complex interplay between viruses and host ncRNAs.
    • ViRBase facilitates the exploration of interaction networks to uncover regulatory mechanisms in viral pathogenesis.