Related Experiment Video
Updated: Aug 10, 2026

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap
Published on: January 16, 2014
Pituitary-adrenal stress response in the absence of brain-pituitary connections
D B Carr1, J C Ballantyne, P F Osgood
1Department of Anesthesia and Medicine, Shriners Burns Institute, Boston, MA 02114.
Abstract:
To examine whether an acute pituitary-adrenal response to stress may occur in vivo in the absence of hypothalamic-pituitary connections, we measured plasma beta-endorphin (beta-EP) and corticosterone (C) in rats after acute thermal injury. beta-EP rose significantly after thermal injury in normal rats and rats bearing pituitary-to-kidney autotransplants but not in animals with pituitary aspiration without reimplantation. Corticosterone responses paralleled beta-EP but were significant only in normal controls. Propranolol pretreatment did not reduce postburn beta-EP and C rises in autotransplanted animals. Therefore, since circulating factors contribute in vivo to pituitary-adrenal responses, the widespread practice of using "stress hormone" responses to quantitate perioperative stress or pain may in some circumstances be flawed.
Related Concept Videos
The Sympathetic Nervous System
Hypothalamic-Pituitary Axis
Anatomy of the Adrenal Glands
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology

