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Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
Associations of radiological features in Mycoplasma pneumoniae pneumonia
Qi Guo1, Hai-Yan Li2, Yi-Ping Zhou1
1Department of Respiratory Medicine, Affiliated Futian Hospital, Guangdong Medical College, Shenzhen, Guangdong, China.
Introduction:
The associations of radiological features with clinical and laboratory findings in Mycoplasma pneumoniae infection are poorly understood. The purpose of this study was to assess the associations.
Material And Methods:
A retrospective cohort study of 1230 patients with community-acquired pneumonia was carried out between January 2005 and December 2009. The diagnosis of M. pneumoniae infection was made using the indirect microparticle agglutinin assay and enzyme-linked immunosorbent assay.
Results:
Females were more susceptible to M. pneumoniae infection. Ground-glass opacification on radiographs was positively associated with M. pneumoniae-IgM titres (rank correlation coefficient (r s) = 0.141, p = 0.006). The left upper lobe was more susceptible to infection with M. pneumoniae compared with other pathogens. More increases in the risk of multilobar opacities were found among older or male patients with M. pneumoniae pneumonia (odds ratio, 1.065, 3.279; 95% confidence interval, 1.041-1.089, 1.812-5.934; p < 0.001, p < 0.001; respectively). Patients with M. pneumoniae pneumonia showing multilobar opacities or consolidation had a significantly longer hospital length of stay (r s = 0.111, r s = 0.275; p = 0.033, p < 0.001; respectively), incurring significantly higher costs (r s = 0.119, r s = 0.200; p = 0.022, p < 0.001; respectively).
Conclusions:
Our study highlighted female susceptibility to M. pneumoniae pneumonia and the association of ground-glass opacification with higher M. pneumoniae-IgM titres. The left upper lobe might be more susceptible to M. pneumoniae infection. Older or male patients with M. pneumoniae pneumonia were more likely to show multilobar opacities. Multilobar opacities and consolidation were positively associated with hospital length of stay and costs.
Insights
This study found females are more susceptible to Mycoplasma pneumoniae pneumonia. Ground-glass opacification and multilobar opacities are associated with increased severity and costs.
Area of Science:
- Infectious Diseases
- Radiology
- Pulmonology
Background:
- The relationship between radiological findings and clinical/laboratory data in Mycoplasma pneumoniae infection requires further elucidation.
- Understanding these associations is crucial for accurate diagnosis and patient management.
Purpose of the Study:
- To investigate the associations between radiological features and clinical/laboratory findings in patients with Mycoplasma pneumoniae pneumonia.
- To identify specific radiographic patterns indicative of M. pneumoniae infection.
Main Methods:
- A retrospective cohort study included 1230 patients diagnosed with community-acquired pneumonia between 2005 and 2009.
- Mycoplasma pneumoniae infection was confirmed using indirect microparticle agglutinin assay and enzyme-linked immunosorbent assay.
Main Results:
- Female patients exhibited higher susceptibility to M. pneumoniae infection.
- Ground-glass opacification correlated positively with M. pneumoniae-IgM titres (r s = 0.141, p = 0.006).
- Multilobar opacities and consolidation were linked to longer hospital stays and higher costs, particularly in older or male patients.
Conclusions:
- Female patients show increased susceptibility to M. pneumoniae pneumonia.
- Radiographic findings like ground-glass opacification and multilobar opacities are associated with infection severity and clinical outcomes.
- The left upper lobe may be a predilection site for M. pneumoniae infection.
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