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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
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Rare primary central nervous system tumors.

Charlotte Dai Kubicky1, Arjun Sahgal2, Eric L Chang3

  • 1Department of Radiation Medicine, Oregon Health Science University , Portland, OR, USA.

Rare Tumors
|October 3, 2014
PubMed
Summary

This review summarizes rare primary central nervous system tumors, focusing on atypical teratoid/rhabdoid tumors and others. It details their pathology and treatment, addressing limited literature on these infrequent brain and central nervous system cancers.

Keywords:
atypical teratoid/rhabdoid tumorchoroid plexus carcinomagangliogliomahemangiopericytomapleomorphic xanthoastrocytoma

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Area of Science:

  • Neurology
  • Oncology
  • Pathology

Background:

  • Primary central nervous system (CNS) tumors affect nearly 70,000 individuals annually in the US.
  • Common CNS tumors like meningiomas and gliomas are well-documented.
  • Limited literature exists on rare CNS tumors, hindering comprehensive understanding and treatment.

Purpose of the Study:

  • To provide an overview of rare primary CNS tumors.
  • To discuss the clinicopathologic and therapeutic aspects of these infrequent neoplasms.
  • To consolidate available data on tumors like atypical teratoid/rhabdoid tumor, choroid plexus carcinoma, ganglioglioma, hemangiopericytoma, and pleomorphic xanthoastrocytoma.

Main Methods:

  • Literature review of infrequently encountered primary CNS tumors.
  • Synthesis of clinicopathologic data.
  • Summary of current therapeutic strategies.

Main Results:

  • Identified key rare primary CNS tumors including atypical teratoid/rhabdoid tumor, choroid plexus carcinoma, ganglioglioma, hemangiopericytoma, and pleomorphic xanthoastrocytoma.
  • Detailed clinicopathologic features for each tumor type.
  • Outlined current treatment approaches and challenges.

Conclusions:

  • Emphasizes the need for increased research and data sharing on rare primary CNS tumors.
  • Highlights the importance of understanding specific tumor biology for effective treatment.
  • Underscores the potential for improved patient outcomes through focused therapeutic strategies for these rare conditions.