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Updated: Apr 23, 2026

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals
Published on: March 30, 2017
Dosage-based parameters for characterization of puff dispersion results
Eva Berbekar1, Frank Harms2, Bernd Leitl2
1Meteorological Institute, University of Hamburg, Germany; Department of Fluid Mechanics, Budapest University of Technology and Economics, Hungary.
Abstract:
A set of parameters is introduced to characterize the dispersion of puff releases based on the measured dosage. These parameters are the dosage, peak concentration, arrival time, peak time, leaving time, ascent time, descent time and duration. Dimensionless numbers for the scaling of the parameters are derived from dimensional analysis. The dimensionless numbers are tested and confirmed based on a statistically representative wind tunnel dataset. The measurements were carried out in a 1:300 scale model of the Central Business District in Oklahoma City. Additionally, the effect of the release duration on the puff parameters is investigated.
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