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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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A Magnetic Resonance Imaging Protocol for Stroke Onset Time Estimation in Permanent Cerebral Ischemia
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Quantitative T2'-mapping in acute ischemic stroke.

Sonja Bauer1, Marlies Wagner1, Alexander Seiler1

  • 1From the Department of Neurology (S.B., A.S., O.C.S.), Institute for Neuroradiology (M.W., E.H.); and Brain Imaging Center (R.D., U.N.), University Hospital Frankfurt, Goethe University, Frankfurt, Germany.

Stroke
|October 4, 2014
PubMed
Summary
This summary is machine-generated.

Quantitative T2'-mapping in acute stroke patients shows reduced T2' values in ischemic tissue, differentiating core from perfusion-impaired areas. This MRI technique aids in stroke assessment.

Keywords:
magneticpositron-emission tomographyresonance imagingstroke

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Area of Science:

  • Neuroimaging
  • Radiology
  • Medical Physics

Background:

  • Quantitative T2 eal-time mapping assesses oxygenation changes, potentially indicating increased oxygen extraction.
  • It is applied to patients with acute large-vessel stroke to evaluate tissue viability.

Purpose of the Study:

  • To assess the utility of quantitative T2 eal-time mapping with motion correction in acute large-vessel stroke.
  • To determine T2 eal-time values within diffusion-weighted imaging lesions and perfusion-restricted tissues.

Main Methods:

  • MRI including diffusion-weighted imaging, perfusion-weighted imaging, and motion-corrected quantitative T2 eal-time mapping was performed in 11 acute stroke patients.
  • Time-to-peak maps were used to define perfusion-restricted areas, and mean T2 eal-time values were compared between lesional and contralateral healthy tissues.

Main Results:

  • T2 eal-time values were significantly reduced in the apparent diffusion coefficient lesion compared to contralateral tissue (83 ms vs. 97 ms).
  • Perfusion-restricted tissue also showed significantly lower T2 eal-time values (93 ms vs. 104 ms) but higher than in the diffusion lesion.
  • The degree of perfusion impairment did not influence median T2 eal-time values.

Conclusions:

  • Motion-corrected T2 eal-time mapping demonstrates gradually declining values from healthy to perfusion-impaired to diffusion-restricted tissue.
  • This technique can distinguish the ischemic core from perfusion-impaired areas in acute stroke.
  • T2 eal-time mapping alone cannot differentiate between penumbral and oligemic tissue.