Related Experiment Video
Updated: Apr 23, 2026
08:54
In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
8.6K
Eosinophil apoptosis and clearance in asthma
1School of Medicine and Dentistry, University of Aberdeen, Scotland, UK.
Journal of Cell Death
|October 4, 2014
Summary
Defects in eosinophil apoptosis and clearance contribute to asthma severity. New therapies targeting these pathways offer potential for improved asthma treatment.
Area of Science:
- Respiratory Medicine
- Immunology
- Cell Biology
Background:
- Asthma is a common respiratory disease with reversible airway obstruction.
- Eosinophilic asthma, a severe phenotype, involves elevated eosinophils linked to disease severity.
- Current asthma therapies have unmet needs, particularly for severe cases.
Purpose of the Study:
- To review mechanisms of eosinophil apoptosis and clearance.
- To discuss evidence linking impaired eosinophil apoptosis and clearance to asthma pathogenesis.
- To explore novel therapeutic strategies targeting eosinophil apoptotic and clearance pathways in asthma.
Main Methods:
- Literature review of studies on eosinophil apoptosis and clearance.
- Analysis of evidence implicating defects in these processes in asthma.
- Discussion of emerging therapeutic targets and treatments.
Main Results:
- Eosinophil persistence in the lungs is associated with inhibited apoptosis and impaired clearance.
- Defects in apoptotic cell removal contribute to airway inflammation and hyper-responsiveness in asthma.
- Novel therapies targeting eosinophil apoptosis and clearance pathways are under development.
Conclusions:
- Dysregulation of eosinophil apoptosis and clearance is a key factor in asthma.
- Targeting these pathways represents a promising therapeutic avenue for asthma management.
- Further research into eosinophil cell death mechanisms could lead to more effective asthma treatments.
Related Concept Videos
01:28Asthma I: Introduction
40
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
40
01:26Asthma-II: Pathophysiology and Classification
4.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.6K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
2.3K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.3K
01:20Asthma: Pathogenesis and Management
1.5K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.5K
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
17
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
17
01:13Asthma III: Clinical Manifestations
25
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
25