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Clinical features of coronary artery ectasia in the elderly
Qiao-Juan Huang1, Yan Zhang2, Xiao-Lin Li2
1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing 100037, China ; Department of Cardiology, Institute of Cardiovascular Diseases, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
Insights
Coronary artery ectasia (CAE) affects elderly patients differently, with higher prevalence of certain conditions and lower survival rates. This study highlights distinct risk factors and outcomes in older individuals with CAE.
Area of Science:
- Cardiology
- Geriatric Medicine
- Vascular Biology
Background:
- Coronary artery ectasia (CAE) is a rare condition characterized by dilation of the coronary arteries.
- Understanding the specific characteristics and outcomes of CAE in elderly populations is crucial for effective clinical management.
Purpose of the Study:
- To investigate the incidence, imaging, and clinical characteristics of coronary artery ectasia in elderly patients.
- To compare the clinical features, imaging findings, and survival rates of elderly and non-elderly patients with CAE.
Main Methods:
- A retrospective analysis of patients who underwent coronary angiography between 2006 and 2012 was performed.
- Patients were divided into elderly (≥65 years) and non-elderly (<65 years) groups.
- Clinical features, imaging characteristics, and 5-year survival rates were compared between the groups.
Main Results:
- The prevalence of CAE in elderly patients was 0.33%.
- Elderly patients with CAE had a higher proportion of females, three-vessel disease, and localized ectasia.
- Elderly patients exhibited lower BMI and a lower percentage of current smokers, but had reduced 5-year cumulative survival compared to the non-elderly group.
Conclusions:
- CAE affects approximately one-third of all CAE patients in the elderly population, with a prevalence of 0.33%.
- Significant differences exist in coronary artery disease risk factors and ectatic characteristics between elderly and non-elderly patients with CAE.
- CAE in the elderly may be associated with an increased risk of mortality.
Objective:
To investigate the incidence, imaging and clinical characteristics in elderly patients with coronary artery ectasia (CAE).
Methods:
A retrospective analysis was conducted on patients with CAE who underwent coronary angiography between January 2006 and December 2012. According to age, the enrolled patients were divided into two groups (elderly group, age ≥ 65 years; non-elderly group, age < 65 years). The clinical feature, imaging characteristics and the 5-year survival rate of the two groups were compared.
Results:
The prevalence of CAE in elderly patients was 0.33%. Patients in elderly group were found to have significantly higher proportion of female (30.1% vs. 10.1%, P < 0.001), three-vessel disease (60.5% vs. 45.2%, P = 0.003) and localized ectasia (55.0% vs. 40.2%, P = 0.003). In addition, body mass index (20.90 ± 2.71 kg/m(2) vs. 22.31 ± 2.98 kg/m(2), P < 0.001) and percentage of current smokers (45.0% vs. 64.6%, P < 0.001) were significantly lower in elderly group. Cumulative survival curves demonstrated reduced 5-year cumulative survival at the follow-up in the elderly group compared with the non-elderly group (88.0% vs. 96.0%, P = 0.002). But the 5-year event free survival rate failed to show a significant difference between the two groups (31.0% vs. 35.0%, P = 0.311).
Conclusion:
The prevalence of CAE in elderly patients was 0.33%, which was about 1/3 of the entire numbers of CAE patients. There were significant differences between the elderly and the non-elderly patients with CAE in terms of coronary artery disease risk factors and coronary artery ectatic characteristics. CAE might be associated with increased mortality risk in the elderly.
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