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A knockout Combo: eradicating AML Stem Cells with TKI plus SIRT1 inhibition
Bernd B Zeisig1, Chi Wai Eric So1
1Leukaemia and Stem Cell Biology Group, Department of Haematological Medicine, Division of Cancer Studies, King's College London, London WC2R 2LS, UK.
Cell Stem Cell
|October 4, 2014
Abstract
None:
SIRT1 inhibition facilitates elimination of CML stem cells by Imatinib, in part via p53 activation. In this issue of Cell Stem Cell, Li et al. (2014) demonstrate a similar role for SIRT1 inhibition in eradicating FLT3-ITD AML stem cells, potentially through a positive feedback loop with c-MYC, highlighting SIRT1 as a potential target in combination cancer therapy.
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