Related Experiment Video
Updated: Apr 23, 2026

06:10
Author Spotlight: Assessment of Cardiac Output Calculation by Thermodilution in Pigs for Effective Perfusion Flow During EVLP
Published on: June 28, 2024
1.3K
Comparison between continuous non-invasive estimated cardiac output by pulse wave transit time and thermodilution
Ashish C Sinha1, Preet Mohinder Singh, Navneet Grewal
1Department of Anaesthesia, Drexel University College of Medicine, Philadelphia, PA, USA.
Annals of Cardiac Anaesthesia
|October 5, 2014
Summary
The estimated continuous cardiac output (esCCO) method shows correlation with the thermodilution (TD) method for cardiac output measurement. However, the current error margin questions its clinical utility for therapeutic decisions.
Area of Science:
- Cardiovascular Physiology
- Critical Care Medicine
- Anesthesiology
Background:
- Cardiac output (CO) monitoring is crucial for patient management in critical care and anesthesia.
- Existing non-invasive CO monitoring methods often involve invasive components.
- The estimated continuous cardiac output (esCCO) system offers a potentially fully non-invasive approach.
Purpose of the Study:
- To evaluate the accuracy and reliability of the esCCO method for continuous cardiac output measurement.
- To compare esCCO measurements against the established thermodilution (TD) method using a pulmonary artery catheter (PAC).
Main Methods:
- A prospective study involving 14 adult surgical patients requiring PAC for CO monitoring.
- Simultaneous CO measurements were recorded using esCCO and TD methods.
- Bland-Altman analysis was employed to assess correlation and concordance between the two methods.
Main Results:
- A significant correlation (r = 0.6, P < 0.001) was observed between esCCO and TD measurements.
- Mean bias was 0.13 L/min with a 95% CI of -4.32 to 4.58 L/min.
- Mean precision was 6.56 L/min with a 95% CI of 2.27 to 10.85 L/min.
Conclusions:
- esCCO represents a truly non-invasive continuous cardiac output monitoring technique.
- While esCCO values correlate with the TD method, the current degree of error raises concerns about its clinical applicability for decision-making.
Related Concept Videos
Pulse
3.9K
The pulse is one of the most fundamental physiological indicators of the body's cardiovascular health. It is the rhythmic expansion and contraction of the arterial walls in response to the pressure generated by the heart's pumping action.
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
Pulse Rate and its Significance
Pulse rate, often measured in beats per minute (bpm), reflects the heart rate (HR), which is influenced by numerous factors such as stress, physical activity, and hormonal changes. A normal resting adult pulse rate falls...
3.9K
Pulse rhythm
1.6K
Pulse rhythm refers to the pattern of pulsations within specific intervals, offering valuable insights into the regularity or irregularity of the heart's beats as observed through the pattern of pulsation within specific intervals. A regular pulse exhibits a consistent heart rate with uniform waveforms and pulsation force, variations of which can be classified as normal, weak, or bounding.
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac...
1.6K
Cardiac Output I:Effect of Heart Rate on Cardiac Output
3.4K
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
3.4K
Equipments Used To Measure Blood Pressure
3.4K
Direct Method
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
3.4K

