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Right Ventricular Epicardial Fibrosis in Mice With Sternal Segment Dislocation.

H A Adissu1, G A Medhanie2, L Morikawa3

  • 1Centre for Modeling Human Disease, Toronto Centre for Phenogenomics, Toronto, ON, Canada Physiology & Experimental Medicine Research Program, The Hospital for Sick Children, Toronto, ON, Canada Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada adissu@lunenfeld.ca.

Veterinary Pathology
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Summary

Sternal segment dislocation in mice can lead to right ventricular fibrosis. This cardiac condition may result from direct injury by displaced sternal segments or associated callus formation.

Keywords:
callusdislocationepicardiumfibrosisheartmicesternum

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Area of Science:

  • Veterinary Pathology
  • Cardiovascular Pathology
  • Skeletal Pathology

Background:

  • Routine histopathology in C57BL/6N mice revealed unexpected sternal segment dislocation.
  • This finding prompted an investigation into potential cardiac consequences.
  • The study aimed to understand the relationship between sternal defects and cardiac pathology.

Purpose of the Study:

  • To determine if cardiac fibrosis is a pathological consequence of sternal segment dislocation in mice.
  • To investigate the pathogenesis of coincident sternal and cardiac lesions.
  • To assess the implications for interpreting phenotypes in mouse models.

Main Methods:

  • Retrospective case series analysis of 1103 mice aged 4-16 weeks.
  • Histopathological evaluation for sternal segment dislocation and cardiac fibrosis.
  • Correlation analysis between sternal dislocation characteristics and fibrosis presence.

Main Results:

  • Sternal segment dislocation identified in 4.6% of mice, predominantly in males, often at the fourth intersternebral joint.
  • Regenerative cartilaginous callus surrounded dislocations in 82.4% of cases.
  • Right ventricular epicardial fibrosis occurred in 43% of mice with sternal dislocation, but not in unaffected mice.

Conclusions:

  • Right ventricular fibrosis is likely caused by direct sternal segment injury or intrathoracic callus.
  • Sternal segment dislocation is a potential confounding factor in mouse models of cardiopulmonary and skeletal diseases.
  • Findings highlight the importance of considering skeletal anomalies in cardiovascular phenotyping.