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Updated: Apr 23, 2026
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Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy
Published on: December 16, 2021
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Arginine metabolism in asthma.
Jeremy A Scott1, Hartmut Grasemann2
1Division of Biomedical Sciences, Department of Health Sciences, Faculty of Health and Behavioural Sciences, Northern Ontario School of Medicine, Lakehead University, 955 Oliver Road Thunder Bay, Ontario P7B 5E1, Canada.
Immunology and Allergy Clinics of North America
|October 6, 2014
Summary
Reduced nitric oxide (NO) in asthma stems from impaired L-arginine metabolism and NO synthase inhibitors. Modulating L-arginine metabolism may correct airway dysfunction in asthma.
Area of Science:
- Respiratory Medicine
- Biochemistry
Background:
- Nitric oxide (NO) plays a crucial role in regulating airway tone and responsiveness.
- Asthma is characterized by airway dysfunction, potentially linked to reduced NO formation.
Purpose of the Study:
- To investigate the role of L-arginine metabolism in NO deficiency in asthma.
- To explore therapeutic strategies targeting L-arginine metabolism for asthma treatment.
Main Methods:
- Analysis of L-arginine metabolism pathways in asthma models.
- Assessment of NO synthase (NOS) activity and substrate availability.
- Evaluation of asymmetric dimethylarginine (ADMA) levels.
Main Results:
- Reduced availability of L-arginine substrate for NOS was observed.
- Increased levels of NO synthase inhibitors like ADMA were found.
- These alterations contribute to decreased NO production and airway dysfunction.
Conclusions:
- Impaired L-arginine metabolism and NOS inhibition contribute to reduced NO formation in asthma.
- Therapeutic modulation of L-arginine metabolism presents a potential strategy to improve airway tone and responsiveness in asthma.
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