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Differences in functional connectivity between alcohol dependence and internet gaming disorder.

Ji Won Han1, Doug Hyun Han1, Nicolas Bolo2

  • 1Department of Psychiatry, Chung Ang University Hospital, Seoul, South Korea.

Addictive Behaviors
|October 6, 2014
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Summary

Internet gaming disorder (IGD) and alcohol dependence (AD) share executive function deficits. However, brain connectivity patterns differ, particularly in the DLPFC and striatal areas, potentially due to unique IGD factors like earlier onset and stimulation.

Keywords:
Alcohol dependenceBrain connectivityImmaturityInternet gaming disorder

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Addiction Research

Background:

  • Internet gaming disorder (IGD) and alcohol dependence (AD) share symptoms like craving and over-engagement.
  • Differences exist in intoxication, age of onset, and sensory stimulation between IGD and AD.

Purpose of the Study:

  • To compare brain functional connectivity in patients with IGD and AD.
  • To identify neurobiological differences and similarities between these two disorders.

Main Methods:

  • Assessed brain functional connectivity in the prefrontal cortex, striatum, and temporal lobe.
  • Included 15 patients with IGD and 16 patients with AD.
  • Evaluated comorbid symptoms of depression, anxiety, and ADHD.

Main Results:

  • Both AD and IGD groups showed positive functional connectivity in the dorsolateral prefrontal cortex (DLPFC), cingulate, and cerebellum.
  • Both groups exhibited negative functional connectivity between the DLPFC and orbitofrontal cortex.
  • AD subjects had positive connectivity between DLPFC, temporal lobe, and striatal areas, while IGD subjects showed negative connectivity in these regions.

Conclusions:

  • AD and IGD share executive function deficits, including impaired self-control and adaptive responding.
  • Distinct negative connectivity in the DLPFC-striatal pathway for IGD may relate to earlier onset and unique stimulation factors.
  • Neuroimaging reveals differing functional connectivity patterns underlying these related behavioral disorders.