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Updated: Apr 23, 2026

Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH
Published on: April 20, 2021
[Morphological changes in the fatty tissue after a single exposure to the ultrasound]
Abstract:
The morphological changes in the fatty tissue of the posterior surface of knee joint were studied in rats (n = 96) using the method of light microscopy 1, 2, 3, 4 and 5 days after a single ultrasonic exposure of various duration (5, 10, 20 min)) in a diagnostic mode. This exposure resulted in hyperemia, lymphostasis and increase of vascular permeability. The degree of changes was found to increase in proportion to the duration of exposure. All the changes detected were reversible, and the majority of them disappeared within 1-2 days. During the practical application, it is necessary to take into account the possibility the induction of cell and tissue damage during the ultrasonographic examinations. Development and application of the measures directed to decrease the edema and to stabilize the vascular wall both during the ultrasonography and immediately after it are expedient. Ultrasonography should be performed only when there are significant medical indications, and to receive the required diagnostic information, the lowest power of the device should be used.
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