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[Structural heterogeneity of human thyroglobulin in relation to its messenger RNA maturation]
Y Malthièry1, B Charvet, M Henry
1Laboratoire de Biochimie Médicale, URA. 178 du CNRS et U. 38 de l'INSERM, Faculté de Médecine, Marseille.
Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1989
Abstract:
One human thyroglobulin cDNA clone present 192 nucleotides deletion which correspond to 64 amino-acid deletion on the protein molecule. We show that this fact figure the exon loss on the mRNA molecule using as template during cDNA synthesis by comparison between mRNA and genomic DNA nucleotide sequences. Different possibility can explain this fact. We retain mainly mistake in mRNA maturation fidelity. This type of event is not an exception and can be an explanation for some pathologies.