Related Experiment Video
Updated: Apr 23, 2026
10:33
Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
4.3K
Pharmacotherapy for uveitis: current management and emerging therapy.
Robert J Barry1, Quan Dong Nguyen2, Richard W Lee3
1Academic Unit of Ophthalmology, Centre for Translational Inflammation, Research, University of Birmingham, UK.
Clinical Ophthalmology (Auckland, N.Z.)
|October 7, 2014
Summary
Uveitis, an inflammatory eye condition, causes significant vision loss. This review discusses ideal drug characteristics and current/emerging therapies for noninfectious uveitis to preserve sight with minimal side effects.
Area of Science:
- Ophthalmology
- Immunology
- Pharmacology
Background:
- Uveitis is a leading cause of vision impairment in the working-age population.
- Noninfectious uveitis, often autoimmune or autoinflammatory, is prevalent in Western countries.
- Current treatments involve immunosuppressive and anti-inflammatory drugs.
Purpose of the Study:
- To outline ideal drug characteristics for uveitis management.
- To review existing and novel therapeutic options for uveitis.
- To emphasize the need for therapies that minimize side effects while preserving visual function.
Main Methods:
- Educational review of scientific literature.
- Analysis of data supporting current and emerging uveitis therapies.
- Synthesis of information on drug properties for intraocular inflammation.
Main Results:
- Ideal uveitis drugs should effectively suppress inflammation and prevent damage.
- Current therapies include various immunosuppressants and anti-inflammatories.
- Emerging therapies show promise for improved efficacy and safety profiles.
Conclusions:
- Effective management of uveitis requires therapies that balance disease suppression with minimal adverse effects.
- Continued development of novel treatments is essential for preserving visual function in uveitis patients.
- Optimizing drug characteristics is key to improving outcomes for this sight-threatening condition.
Related Concept Videos
01:29Inflammatory Bowel Disease IV: Pharmacological Management
1.1K
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
1.1K
01:27Open Angle Glaucoma: Treatment
1.0K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
01:14Myocarditis III: Medical Management
341
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
341
01:17Pericarditis III: Medical Management
579
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
579
01:26Nephrotic Syndrome II : Assessment and Medical Management
403
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
403