Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

6.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
6.9K
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

1.1K
1.1K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

2.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Redox- and Photo-Responsive Fe<sup>3+/2+</sup>-Cross-Linked Carboxymethyl Cellulose Methacrylate Dissipative Gels: Synthesis and Applications.

ACS applied materials & interfaces·2026
Same author

Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics.

Signal transduction and targeted therapy·2026
Same author

Constructing Intrinsically Safe Lithium-Ion Battery Energy Storage via Gradient-Laminated Ceramifiable Silicone Foams.

Nano-micro letters·2026
Same author

Strongly Correlated Electron Systems in Triple Metal Atoms Trigger Atomic-Level Structure Resonance for Durable and Efficient Ammonia Electrosynthesis.

Angewandte Chemie (International ed. in English)·2026
Same author

Nucleophiles as Reaction Switches: Dearomative Multifunctionalization of Isoquinoliniums to Rigid Bridged-Ring Architectures.

Organic letters·2026
Same author

Photoactivated Signaling Networks using DNA-Based Synthetic Organelles as Biomimetic Protocells.

Angewandte Chemie (International ed. in English)·2026
Same journal

Implication of the Strand-Specific Imprinting and Segregation Model: Integrating <i>in utero</i> Hormone Exposure, Stem Cell and Lateral Asymmetry Hypotheses in Breast Cancer Aetiology.

Hereditary genetics : current research·2021
Same journal

Epigenomic Indicators of Age in African Americans.

Hereditary genetics : current research·2016
Same journal

Metformin- A Promising Agent for Chemoprevention in <i>BRCA1</i> Carriers.

Hereditary genetics : current research·2015
Same journal

Current status in diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura.

Hereditary genetics : current research·2014
Same journal

ADAMTS13, TTP and Beyond.

Hereditary genetics : current research·2014
Same journal

Epistatic Control of Mammary Cancer Susceptibility in Mice may Depend on the Dietary Environment.

Hereditary genetics : current research·2014
See all related articles

Related Experiment Video

Updated: Apr 23, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

19.8K

Triple Negative Breast Cancer - An Overview.

Kartik Aysola1, Akshata Desai2, Crystal Welch1

  • 1Cancer Biology Program, Department of OB/GYN, Morehouse School of Medicine, Georgia Cancer Center for Excellence, Grady Health System, Atlanta, GA 30303, USA.

Hereditary Genetics : Current Research
|October 7, 2014
PubMed
Summary
This summary is machine-generated.

Triple Negative Breast Cancer (TNBC) is an aggressive cancer lacking targeted therapies, often affecting young women with BRCA1 mutations. A newly identified BRCA1 trafficking pathway offers future hope for developing targeted treatments for TNBC.

Keywords:
BCL-2BRCA1CISPLATINEGFRHedgehogNOTCHPARPTNBCUBC9WNT/B-CATENIN

More Related Videos

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

4.2K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.2K

Related Experiment Videos

Last Updated: Apr 23, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

19.8K
Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
13:19

Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery

Published on: April 26, 2024

4.2K
Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
07:45

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

6.2K

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Triple Negative Breast Cancer (TNBC) is defined by negative estrogen receptor (ER), progesterone receptor (PR), and HER2 expression via immunohistochemistry (IHC).
  • TNBC disproportionately affects young African American and Hispanic women, frequently associated with BRCA1 gene mutations.
  • This cancer subtype exhibits aggressive behavior and a lack of specific targeted therapies, posing significant clinical challenges.

Purpose of the Study:

  • To review current and emerging novel signaling pathways for therapeutic strategies against TNBC.
  • To highlight the potential of a recently discovered BRCA1 trafficking pathway for future targeted therapy development.

Main Methods:

  • Literature review of current research on TNBC signaling pathways.
  • Analysis of recent findings on BRCA1 gene function and cellular trafficking.
  • Exploration of potential therapeutic targets based on identified pathways.

Main Results:

  • TNBC is a heterogeneous disease with a distinct molecular profile and aggressive clinical course.
  • BRCA1 gene mutations are prevalent in certain demographics affected by TNBC.
  • A novel BRCA1 trafficking pathway has been recently identified.

Conclusions:

  • The identified BRCA1 trafficking pathway presents a promising avenue for developing targeted therapies for TNBC.
  • Further research into this pathway could lead to novel treatment strategies for patients with TNBC, particularly those with BRCA1 mutations.