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Intersection of AHR and Wnt signaling in development, health, and disease

Andrew J Schneider1, Amanda M Branam2, Richard E Peterson3

  • 1School of Pharmacy and Molecular and Environmental Toxicology Center University of Wisconsin, Madison, WI 53705, USA. ajschnei@wisc.edu.

International Journal of Molecular Sciences
|October 7, 2014
PubMed

Insights

Aryl hydrocarbon receptor (AHR) and Wnt signaling pathways are crucial for development. This review explores their crosstalk, finding that TCDD-induced AHR activation disrupts Wnt signaling, impairing fetal prostate development.

Area of Science:

  • Developmental Biology
  • Molecular Signaling
  • Toxicology

Background:

  • Aryl hydrocarbon receptor (AHR) and Wnt signaling pathways are evolutionarily conserved pathways essential for normal development and health.
  • Dysregulation of AHR and Wnt signaling is linked to developmental defects and various diseases.
  • While individually well-studied, the crosstalk between AHR and Wnt signaling remains underexplored.

Purpose of the Study:

  • To review the roles of AHR and Wnt signaling in development and disease.
  • To elucidate the molecular mechanisms of AHR and Wnt pathway activation.
  • To investigate the intersection and potential crosstalk between AHR and Wnt signaling pathways.

Main Methods:

  • Literature review of AHR and Wnt signaling pathways.
  • Analysis of existing research on AHR-Wnt pathway interactions.
  • Summary of recent findings on TCDD's effect on Wnt signaling and fetal prostate development.

Main Results:

  • Aryl hydrocarbon receptor (AHR) and Wnt signaling are critical for development.
  • 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure disrupts Wnt signaling.
  • TCDD-induced disruption of Wnt signaling impairs fetal prostate development.

Conclusions:

  • Understanding AHR and Wnt signaling crosstalk is vital for developmental biology and toxicology.
  • Experimental evaluation of these pathways is necessary to uncover complex interactions.
  • TCDD's adverse effects on fetal development highlight the importance of studying pathway intersections.

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