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Neuropsychiatric complications in a patient with Marfan syndrome

Chin-Pang Lee1, Chun-Lin Chu1, Chia-Yih Liu1

  • 11 Department of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Acta Neuropsychiatrica
|October 8, 2014
PubMed
Abstract

Insights

Marfan syndrome (MFS), a genetic disorder affecting connective tissues, is linked to psychiatric conditions. This case highlights cerebral infarction as a potential cause of mental dysfunction in MFS patients.

Area of Science:

  • Genetics and Medicine
  • Neuroscience

Background:

  • Marfan syndrome (MFS) is an autosomal dominant genetic disorder caused by fibrillin-1 gene mutations.
  • MFS affects cardiovascular, skeletal, and ocular systems, and is associated with increased susceptibility to psychiatric conditions like schizophrenia.

Purpose of the Study:

  • To raise awareness of the association between Marfan syndrome and psychiatric conditions.
  • To improve clinical management of MFS patients by recognizing and mitigating psychiatric risks.

Main Methods:

  • Case report of a 40-year-old male patient with Marfan syndrome.
  • Detailed observation of patient's neurological and cognitive manifestations.

Main Results:

  • The patient presented with incoherent speech, impaired cognitive function, and social dysfunction.
  • These symptoms were attributed to bilateral cerebral infarction, a neurovascular complication linked to MFS.

Conclusions:

  • Cerebral infarction is a potential neurovascular complication of Marfan syndrome.
  • Recognizing this association is crucial for comprehensive patient care and management.

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