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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Rheumatic Heart Disease IV: Nursing Management01:20

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AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
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Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
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Detecting Migration and Infiltration of Neutrophils in Mice
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[Rheumatoid neutrophilic dermatitis].

G Titeca1, L Goudetsidis1, A Laka2

  • 1Service de dermatologie, clinique Notre-Dame-de-Grâce, 212, chaussée de Nivelles, 6041 Gosselies, Belgique.

Annales De Dermatologie Et De Venereologie
|October 8, 2014
PubMed
Summary

Rheumatoid neutrophilic dermatitis (RND) is a rare skin manifestation of rheumatoid arthritis (RA). This case report highlights successful treatment of RND with topical corticosteroids.

Keywords:
Dermatose neutrophilique rhumatoïdeInfiltrat dermique neutrophiliqueNeutrophilic dermal infiltratePolyarthrite rhumatoïdeRheumatoid arthritisRheumatoid neutrophilic dermatitis

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Area of Science:

  • Dermatology
  • Rheumatology
  • Immunodermatology

Background:

  • Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease.
  • RA commonly affects joints but can involve extra-articular organs.
  • Cutaneous manifestations, like rheumatoid neutrophilic dermatitis (RND), are infrequent in RA.

Observation:

  • A 64-year-old female patient with progressive RA presented with a forearm, elbow, and scalp rash.
  • Skin biopsy revealed a dense dermal neutrophilic infiltrate and leukocytoclasia without vasculitis.
  • The histological findings confirmed a diagnosis of rheumatoid neutrophilic dermatitis (RND).

Findings:

  • Rheumatoid neutrophilic dermatitis (RND) is an uncommon cutaneous finding in rheumatoid arthritis (RA).
  • Clinical presentation of RND includes plaques, nodules, or urticarial lesions.
  • Histopathology is key for diagnosing RND, showing neutrophilic infiltrate and leukocytoclasia.

Implications:

  • RND lesions often resolve with RA treatment or spontaneously.
  • Topical corticosteroids provided successful treatment for the patient's RND.
  • Systemic therapies, including dapsone, may be considered for managing RND in RA.