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Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
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Intercellular protein movement: deciphering the language of development.

Kimberly L Gallagher1, Rosangela Sozzani, Chin-Mei Lee

  • 1Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email: gallagkl@sas.upenn.edu , leechin@sas.upenn.edu.

Annual Review of Cell and Developmental Biology
|October 8, 2014
PubMed
Summary
This summary is machine-generated.

Coordinated development in multicellular organisms relies on non-cell-autonomous signals. This review explores mobile transcriptional regulators and their movement through plasmodesmata in plants, crucial for development.

Keywords:
Arabidopsis developmentcell-to-cell signalingnon-cell-autonomous proteinsplasmodesmata

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Area of Science:

  • Plant Biology
  • Developmental Biology
  • Cell Signaling

Background:

  • Multicellular development requires coordinated cell specialization via signaling.
  • Non-cell-autonomous signals are key for coordinating developmental processes.
  • Intercellular transport of signals like transcription factors, hormones, and peptides is vital in plants.

Purpose of the Study:

  • To review transcriptional regulators that move between plant cells.
  • To discuss how symplasmic continuity influences and is influenced by development.
  • To examine models of mobile signal transport via plasmodesmata and its inhibition.

Main Methods:

  • Literature review of existing research on mobile signals in plant development.
  • Analysis of studies investigating transcriptional regulators trafficking between cells.
  • Examination of research on plasmodesmata function and regulation.

Main Results:

  • Numerous non-cell-autonomous signals controlling plant development have been identified.
  • Transcriptional regulators are shown to traffic between cells, impacting development.
  • Changes in symplasmic continuity are intrinsically linked to developmental processes.

Conclusions:

  • Mobile signals, particularly transcriptional regulators, are essential for plant development.
  • Understanding plasmodesmata-mediated transport is critical for deciphering developmental coordination.
  • New tools and approaches are needed to further investigate protein movement in development.