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Published on: July 22, 2011
The advantage of being a low responder
I R Cohen1, D M Altmann, A Friedman
1Department of Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel.
Abstract:
Immune response genes determine the magnitude of many immune responses. A low response is often ascribed to a genetic defect. Here Irun Cohen argues that a poor response instead reflects a heightened sensitivity to the conditions in which antigen is encountered. When these are optimal the response is normal. Poor responders thus have the advantage of a greater fexibility of response over individuals who respond strongly regardless of prevailing circumstances.
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