Related Experiment Video
Updated: Apr 22, 2026

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
The veto phenomenon and T-cell regulation
1Department of Immunology, University of Toronto and the Ontario Cancer Institute, Toronto, Canada M5S 1A8.
Abstract:
Lymphocytes bearing anti-self receptors are produced during ontogeny, yet normally the immune system does not actively react against self components. Instead, it is thought that selfreactive cells are either deleted or, failing this, suppressed by regulatory networks similar to those limiting the immune response against non-self determinants. Recognition events between T cells play a central role in both mechanisms. Here Rick Miller describes 'veto cells' which can inactive (apparently permanently) T cells which recognize them. Some T cells can themselves serve as veto cells. The veto mechanism has been shown capable of eliminating T cells reactive against self class I major histocompatibility complex (MHC) antigens and against antigen in association with either class I or class II MHC products.
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