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Updated: Apr 22, 2026

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
Published on: February 21, 2018
Why do hemopoietic growth factor receptors interact with each other?
1The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, 3050 Victoria, Australia.
Abstract:
Hemopoietic growth factors (colony-stimulating factors, CSFs) interact with distinct cellular receptors that recognize only their cognate ligand. Yet, like other growth factor/receptor systems, the binding of one type of CSF to its receptor can 'down-modulate' the availability of a different tyoe of CSF receptor. In this article Nicos Nicola discusses the distinctive pattern of] CSF-receptor modulations and suggests a novel interpretation of such modulations as a means of coupling receptor-derived signals which is consistent with the known biology of the system.
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