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Updated: Apr 22, 2026

Isolation and Activation of Murine Lymphocytes
Published on: October 30, 2016
Cellular aspects of polyclonal activation of B lymphocytes
1Department of Immunopathology, Scripps Clinic and Research Foundation, La Jolla, California 92037, U.S.A.
Abstract:
The responses of B lymphocytes to exogenous stimulation can be antigen-specific or non-specific. Non-specific stimulation by a single agent activates a multitude of clones of B cells, each secreting antibody of pre-programmed specificity. In this review Michael Goodman examines how polyclonal activation of B cells can be achieved, and the relationship between such stimulation and DNA synthesis, considers the evidence for and against the existence of B-cell subpopulations responsive to different polyclonal activators, and looks at the ways in which polyclonal activation is regulated.
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