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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Reproductive Cloning01:27

Reproductive Cloning

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Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
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Related Experiment Video

Updated: Apr 22, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL
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HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

Published on: April 11, 2011

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Human T-cell clones find ever wider application.

F Emmrich1, S Meuer2

  • 1Max-Planck-Institut fur Immunbiologie, D-7800 Freiburg, FRG.

Immunology Today
|October 8, 2014
PubMed
Summary
This summary is machine-generated.

Human T lymphocyte clones enable prolonged in vitro study of cell surface molecules, T-cell functions, immune disorders, and vaccine screening. Collaboration across disciplines is key to advancing this research.

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Single-cell Screening Method for the Selection and Recovery of Antibodies with Desired Specificities from Enriched Human Memory B Cell Populations
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Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Human T lymphocytes are crucial for immune responses.
  • Understanding T-cell functions requires advanced in vitro models.
  • Prolonged propagation of T cells enables detailed investigation.

Purpose of the Study:

  • To highlight the potential of human T lymphocyte clones for diverse research areas.
  • To emphasize the need for interdisciplinary collaboration in T-cell research.
  • To discuss applications ranging from basic science to vaccine development.

Main Methods:

  • Utilizing clones of human T lymphocytes.
  • Employing methods for prolonged in vitro propagation of T cells.
  • Bringing together specialists from various scientific fields.

Main Results:

  • Established T lymphocyte clones facilitate in-depth physiological studies.
  • Enabled investigation into T-cell heterogeneity and functional repertoires.
  • Provided a platform for studying immune disorder pathophysiology and vaccine screening.

Conclusions:

  • Human T lymphocyte clones are a powerful tool for immunological research.
  • Interdisciplinary collaboration is essential for maximizing the potential of T-cell research.
  • This technology supports advancements in understanding immune regulation, disease, and therapeutics.