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On the necessity of the idiotype network: studies with nude mice

H M Edinger1, C H Heusser

  • 1Basel Institute for Immunology (founded and supported by F. Hoffmann-La Roche and Co., Ltd, Basel, Switzerland) and Pharmaceutical Research Laboratories, Ciba-Geigy Ltd, Basel, Switzerland.

Immunology Today
|October 8, 2014
PubMed

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...