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Published on: August 19, 2014
Ia antigens on non-lymphoid tissues their origins and functions
D F Nixon1, J P Ting, J A Frelinger
1Department of Microbiology, University of Southern California School of Medicine, Los Angeles, CA 90033, U.S.A.
Abstract:
Ia molecules are encoded in the 1 region of the mouse major histocompatibility complex (MIX) and expressed as surface antigens on certain immunologically active cells (reviewed in Ref. 1). B cells, subsets of T helper and T suppressor cells and accessory, antigen-presenting cells are Ia-positive (Ia+) while T killer cells and natural killer cells are not. This article discusses the nature and function of Ia+ cells found in non-lymphoid tissues, some of which are immunologically involved while others are not obviously so.
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