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The use of myeloma cells to study immunoregulatory mechanisms

R G Lynch1, G L Milburn

  • 1Division of Experimental Pathology, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.

Immunology Today
|October 8, 2014
PubMed

A number of recent observations have established that murine myeloma cells are capable of responding to the same kinds of immunoregulatioy signals that so precisely govern the expansion and differentiation of non-neoplastic B-cell clones. However, myeloma cells have the distinct advantage of being a monoclonal and homogeneous source of target cells with which to investigate the cellular and molecular details of B-cell immunoregulation. In this review Richard Lynch and Gary Milburn summarize their results using the murine myeloma MOPC-315 to study immunoregulation.

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