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Updated: Apr 22, 2026

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain
Published on: October 25, 2016
The T-cell antigen receptor gamma gene: rearrangement and cell lineages
1Cancer Research Laboratory, Department of Microbiology and Immunology, University of California, Berkeley, California 94720, USA.
Abstract:
Most adult T cells have a T-cell antigen receptor composed of αß heterodimers in a complex with the CD3 antigen. Immature thymocytes, however, can express CD3-associated heterodimers of a γ chain and another poorly characterized chain ('δ'). Here James Allison and Lewis Lanier suggest that thymocytes can develop along two mutually exclusive ontological pathways, giving rise to T cells that express either αß or γδ heterodimers, but not both or any other heterodimeric combination.
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