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Related Experiment Video

Updated: Apr 22, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
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HIV infection: facts and hypotheses.

D Klatzmann1, J C Gluckman

  • 1Laboratoire d'Immunologie Néphrologique et Transplantation Hôpital, La Pitié-Salpétrière, 75634 Paris Cedex 13, France.

Immunology Today
|October 8, 2014
PubMed
Summary

The human immunodeficiency virus (HIV), the cause of acquired immunodeficiency syndrome (AIDS), was identified in 1983. A model for HIV pathogenicity is proposed, detailing host-virus interactions in disease progression.

Area of Science:

  • Virology
  • Immunology
  • Epidemiology

Background:

  • The etiological agent of acquired immunodeficiency syndrome (AIDS) was first isolated in 1983.
  • Initial isolates were named lymphadenopathy associated virus (LAV), HTLV-III, or ARV.
  • International consensus proposed the name human immunodeficiency virus (HIV) for these related viruses.

Purpose of the Study:

  • To propose a general model for HIV pathogenicity.
  • To explain the stepwise evolution from primary infection to disease.

Main Methods:

  • Review of biological and molecular characteristics of HIV isolates.
  • Analysis of epidemiological and clinical observations.
  • Development of a host-virus interaction model.

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Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
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Main Results:

  • Confirmation that LAV, HTLV-III, and ARV are isolates of the same virus, HIV.
  • A proposed model illustrating the complex pathway of pathogenicity.
  • Understanding the stepwise progression from infection to disease.

Conclusions:

  • HIV is the causative agent of AIDS.
  • A model of pathogenicity based on host-virus interactions provides insight into disease progression.
  • Further research into HIV biology and host interactions is crucial for understanding and managing AIDS.