Related Experiment Video
Updated: Apr 22, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
The effect of HLA matching on kidney-graft survival
1Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, U.K.
Abstract:
All human skin grafts, even those perfectly matched for HLA antigens, are eventually rejected, some acutely, while over half the completely mismatched transplanted kidneys survive for more than a year. There is no doubt that the HLA system is the major human histocompatibility complex but, as Alan Ting shows in this article, the assessment of its influence on graft outcome is complex.
Related Concept Videos
Kidney Transplant I: Introduction
Kidney Transplant II: Surgical Procedure
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant III: Nursing Management
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
Cell-mediated Immune Responses

