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Updated: Apr 22, 2026

Generation of Human Alloantigen-specific T Cells from Peripheral Blood
Published on: November 21, 2014
Allele-specific alien-driven diversity, immune responsiveness and MHC-restriction
1Departments of Pediatrics, Human Oncology and Genetics, University of Wisconsin, Madison, Wisconsin, USA.
Abstract:
Synthetic and environmental antigens are presented to T cells in the context of MHC determinants but, for certain antigens, some determinants are more effective than others(1-3), perhaps because they make an optimal or more immunogenic physical association with the antigen(2,3). Here, Randy Mandell and Paul Sondel use the concepts of immune crossreactivity and 'alien' MHC antigens to propose an alternative explanation for allele-specific MHC-restriction of T-cell responses to certain antigens. Such allele-specific, alien-driven diversity may also be relevant to the relationship between MHC determinants and immune response genes.
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