Transplantation tolerance and immunosuppression following liver grafting in rats

Liver grafts between certain inbred rat strains seem to contradict the normal rules of transplantation by surviving and inducing tolerance in animals which would rapidly reject grafts of other organs from the liver donor. A liver graft also has remarkable powers of immunosuppression and can reverse rejection reactions in progress in distant sites. In this review, Naoshi Kamada discusses cellular and molecular mechanisms associated with liver-induced unresponsiveness.