[Characteristics of cellular immunosuppression models of allotransplantation reactions]

Two developed experimental models based on induction of suppression by alloantigens in mice and on testing of its effect on the level of proliferative immune reaction during systemic or local adoptive transfer of spleen suppressor cells to syngeneic mice were used. Formation of immunosuppressive mechanisms has been shown to depend on alloantigen (H-2, Mls) properties. Dynamics of suppression development, a degree of its specificity, role of T cells and macrophages in suppression and sensitivity to cyclophosphamide were studied. The possibility to employ the proposed models in the studies of immunosuppression peculiarities during tumour development is considered.