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MHC-restricted recognition by antigen-specific B cells: fact or artefact?
1Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20205, USA.
Immunology Today
|October 8, 2014
Summary
T cells recognize antigens with major histocompatibility complex (MHC) molecules, while B cells recognize antigens directly. This fundamental difference suggests distinct, complementary roles for T cells and B cells in host defense.
Area of Science:
- Immunology
- Cellular Biology
Background:
- T cells and B cells are key antigen-specific lymphoid cells.
- Established understanding suggests differing antigen recognition mechanisms between T and B cells.
Purpose of the Study:
- To discuss a formulation explaining distinct functions of T cells and B cells in host defense.
- To reconcile accepted notions of T cell and B cell antigen recognition.
Main Methods:
- Conceptual discussion and formulation of immune function.
- Review of established immunological principles regarding T and B cell recognition.
Main Results:
- T cells require recognition of nominal antigens in association with major histocompatibility complex (MHC) products.
- B cells recognize antigens directly, without a requirement for self-MHC association.
Conclusions:
- T cells and B cells possess distinct antigen recognition capabilities.
- These distinct capabilities likely contribute to complementary functions in host defense mechanisms.
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