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Tolerance in T-cell clones

M Feldmann1, E D Zanders2, J R Lamb3

  • 1ICRF Tumour Immunology Unit, Zoology Department, University College London, London WC 1E 6BT, UK.

Immunology Today
|October 8, 2014
PubMed

The interaction of antigen with immunologically competent cells may lead either to the induction of an immune response or to a state of antigen specific unresponsiveness complete orpartial, which is often called immunological 'tolerance'. This is believed to be a major mechanism of discrimination between self and non-self(1-3). In this review Marc Feldmann and his colleagues discuss new insights into T-cell tolerance in vivo and in vitro, and discuss their significance for our understanding of mechanisms of immune activation and regulation.

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