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The basis of autoimmunity in MRL-lpr/lpr mice: a role for self Ia-reactive T cells

Y J Rosenberg¹, A D Steinberg, T J Santoro

¹Section on Cellular Immunology, Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20205, USA.

Immunology Today

|October 8, 2014

Abstract:

Murine models of systemic lupus eRythematosus (SLE) have significantly contributed to our understanding of human autoimmunity. One such strain, the MRL-lpr/lpr, spontaneously develops an autoimmune disease manifested clinically by arthritis, vasculitis, immune-complex glomerulonephritis and autoantibody production(1-3). In this article Yvonne Rosenberg and her colleagues suggest a theoretical basis for the development of autoimmunity in MRL-lpr/lpr mice.

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