Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

5.6K
5.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

4.9K
4.9K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

3.8K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.8K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

7.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preventative strategies for low anterior resection syndrome.

Techniques in coloproctology·2023
Same author

PROSPECT guideline for tonsillectomy: systematic review and procedure-specific postoperative pain management recommendations.

Anaesthesia·2020
Same author

Anesthetic management for cesarean delivery for a parturient with metaphyseal dysplasia and hypophosphatemic rickets.

International journal of obstetric anesthesia·2020
Same author

A rare presentation of a paediatric patient with acute otomastoiditis media caused by mycobacterium tuberculosis resulting in intracranial complications.

Journal of surgical case reports·2019
Same author

Upper airway obstruction assessment: Peak inspiratory flow and clinical COPD Questionnaire.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2018
Same author

The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer.

Oncogene·2017

Related Experiment Video

Updated: Apr 22, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

972

Growth factors and oncogenes.

A Burgess1

  • 1Ludwig Institute for Cancer Research, Melbourne Tumour Biology Unit, Post Office Royal Melbourne Hospital, Victoria 3050, Australia.

Immunology Today
|October 8, 2014
PubMed
Summary

Growth factors regulate normal cell proliferation. Understanding growth factors, their receptors, and actions is key to deciphering cancer-causing molecular lesions and their similarities in normal and transformed cells.

Area of Science:

  • Molecular biology
  • Cell biology
  • Biochemistry

Background:

  • Cell proliferation and differentiation are fundamental biological processes.
  • Growth factors are critical regulators of normal cell growth.
  • Understanding these processes is crucial for cancer research.

Purpose of the Study:

  • To discuss similarities in molecular regulation of proliferation and differentiation.
  • To explore normal and transformed cells across different tissues.
  • To highlight the role of growth factors and their receptors in cancer.

Main Methods:

  • Review of existing literature on growth factors and oncogenes.
  • Comparative analysis of molecular regulation in normal and transformed cells.
  • Discussion of experimental systems in tissue culture.

More Related Videos

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

9.4K
A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
06:36

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion

Published on: April 24, 2015

10.3K

Related Experiment Videos

Last Updated: Apr 22, 2026

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

972
A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
09:52

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication

Published on: September 20, 2016

9.4K
A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
06:36

A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion

Published on: April 24, 2015

10.3K

Main Results:

  • Growth factor chemistry and function are increasingly understood.
  • Knowledge of growth factors, receptors, and signaling pathways is advancing.
  • Similarities exist in the molecular regulation of normal and cancer cells.

Conclusions:

  • Understanding growth factor signaling is pivotal for cancer research.
  • Molecular insights into cell regulation can illuminate cancer development.
  • Comparative studies reveal conserved mechanisms in normal and aberrant cell growth.