A new classification of mouse VH sequences

Renate Dildrop has compared heavy chain variable-region sequences of mouse immunoglobulins at the amino acid level and determined the homology within the coding region of the entire VHgene segment. The resulting homology plot defines seven separate groups of VHgene sequences which differ from the five groups of variable-region sequences in the previous classification of Kabat et al.' and accordfully with the recently identified chromosomal clusters of VHgenes.