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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Statins, mood, sleep, and physical function: a systematic review.

Kristopher J Swiger1, Raoul J Manalac, Michael J Blaha

  • 1Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, 1800 Orleans Street, Zayed 7125, Baltimore, MD, 21287, USA.

European Journal of Clinical Pharmacology
|October 9, 2014
PubMed
Summary
This summary is machine-generated.

This review found limited evidence that statins negatively impact mood, sleep, or physical function. Studies suggesting adverse effects often had methodological flaws, indicating no significant harm from statin use.

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Area of Science:

  • Cardiovascular Pharmacology
  • Clinical Therapeutics
  • Patient-Reported Outcomes

Background:

  • Statins are widely prescribed cholesterol-lowering drugs.
  • Concerns exist regarding potential adverse effects on quality of life.
  • The impact of statins on mood, sleep, and physical function requires thorough evaluation.

Purpose of the Study:

  • To systematically evaluate the effects of statin therapy on mood, sleep, and physical function.
  • To assess the quality of evidence regarding statin-associated adverse effects on quality of life.

Main Methods:

  • Systematic literature search of major biomedical databases (MEDLINE/PubMed, EMBASE, Cochrane Central Register).
  • Inclusion of all patient populations and study types comparing statins to placebo or no treatment.
  • Outcome measures focused on mood, sleep, and physical function.

Main Results:

  • Most studies (88% observational, 66% and 100% of randomized trials for mood endpoints) did not support negative mood effects from statins.
  • Fewer studies investigated statin effects on sleep and physical function.
  • Studies reporting negative effects often contained biases (e.g., confounding, lack of blinding, multiple testing).

Conclusions:

  • Available evidence suggests statins do not adversely affect mood, sleep, or physical function.
  • Studies indicating adverse effects are associated with a higher risk of bias.
  • High-quality, prospective studies are needed, particularly for sleep and physical function, to identify vulnerable patient groups.