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Updated: Apr 22, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
[Acute liver failure following heat stroke after participating in a running event]
Line Borregaard1, Bente Kjaer Lyngsoe, Christian Fenger-Eriksen
1Anæstesiologisk Afdeling, Hospitalsenheden Horsens, Sundvej 30, 8700 Horsens. lineborr@rm.dk.
Abstract:
We describe two cases of acute liver failure following heat stroke after participation in a running event. At admission both patients had a severely affected circulation, altered consciousness and hyperthermia, with a core temperature of > 40 degrees Celsius. Within the first 24 hours both patients suffered from acute liver failure, kidney failure and coagulopathy. No other causes but dehydration and hyperthermia could explain the liver failure. The treatment of heat stroke is symptomatic, but liver transplantation may be an option in case of fulminant liver failure.
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