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Clinical experience with ciprofloxacin.

J R Hann, B F Sudderth, R V Baker

    The Journal of the Arkansas Medical Society
    |September 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

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    Ciprofloxacin demonstrated high efficacy in treating various infections, achieving clinical cure or improvement in 88.9% of patients. Adverse reactions were infrequent, with only 16% experiencing side effects, and discontinuation due to adverse events was rare.

    Area of Science:

    • Infectious Diseases
    • Pharmacology

    Background:

    • Ciprofloxacin is a broad-spectrum fluoroquinolone antibiotic.
    • Effective treatment of diverse bacterial infections is crucial.

    Purpose of the Study:

    • To evaluate the efficacy and safety of ciprofloxacin in treating various infections.

    Main Methods:

    • A multicenter study involving 30 patients.
    • Patients received ciprofloxacin at a mean daily dosage of 1000 mg for a mean duration of 10.6 days.
    • Infections included microbiologically proven and chronic cases.

    Main Results:

    • Bacteriologic cure/improvement was observed in 92.3% of microbiologically proven infections.
    • Clinical cure/improvement was achieved in 88.9% of all 30 infections.

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  • Adverse drug reactions (ADRs) occurred in 16% of patients, with only two definitely related to ciprofloxacin.

    • Conclusions:

    • Ciprofloxacin is an effective and generally well-tolerated antibiotic for various infections.
    • Low rates of ADRs and discontinuation suggest a favorable safety profile.