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Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
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[Natalizumab can induce progressive multifocal leucoencephalopathy]

Asta Theódórsdóttir1, Morten Blaabjerg, Masoud Falah

  • 1Ásta Theódórsdóttir, Neurologisk Afdeling, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C.

Ugeskrift for Laeger
|October 9, 2014
PubMed

A 41-year-old woman with relapsing-remitting multiple sclerosis came to the outpatient-clinic, prior to a scheduled infusion with natalizumab. She had been treated with natalizumab for four years. Prior to treatment she did not wish to have her John Cunningham virus status tested. At the consultation she appeared disoriented and answered questions inadequately. An MRI was consistent with progressive multifocal leucoencephalopathy, and treatment with plasmapheresis was startet immediatly. The patient deceased four months later.

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