Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cellular mechanisms in diabetic neuropathy].

T Brismar

    Lakartidningen
    |August 30, 1989
    PubMed
    Summary

    Distal diabetic neuropathy may stem from reduced sodium potassium ATPase activity. This leads to sodium buildup, cell swelling, and myelin damage, explaining nerve degeneration in diabetic patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chemerin inhibits vascular calcification through ChemR23 and is associated with lower coronary calcium in chronic kidney disease.

    Journal of internal medicine·2019
    Same author

    Implant density is not related to patient-reported outcome in the surgical treatment of patients with idiopathic scoliosis.

    The bone & joint journal·2018
    Same author

    The maturation of mismatch negativity networks in normal adolescence.

    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2015
    Same author

    Is training essential for interpreting cardiac computed tomography?

    Acta radiologica (Stockholm, Sweden : 1987)·2009
    Same author

    Amplitude and phase relationship between alpha and beta oscillations in the human electroencephalogram.

    Medical & biological engineering & computing·2006
    Same author

    Phase synchronization between alpha and beta oscillations in the human electroencephalogram.

    Neuroscience·2005

    Area of Science:

    • Neuroscience
    • Diabetology
    • Cellular Biology

    Context:

    • Distal diabetic neuropathy (DDN) pathogenesis remains unclear.
    • Experimental studies offer insights into potential mechanisms.
    • Animal models provide cellular and molecular parallels to human nerve fibers.

    Purpose:

    • To postulate a central mechanism in the pathogenesis of distal diabetic neuropathy.
    • To elucidate the role of sodium potassium ATPase activity in DDN.

    Summary:

    • Reduced sodium potassium ATPase activity is proposed as a key factor in DDN.
    • This enzyme dysfunction causes intracellular sodium accumulation and cellular edema.
    • Myelin detachment at the nodes of Ranvier is a consequence, contributing to nerve damage.

    Impact:

    • Provides a potential unifying mechanism for distal diabetic neuropathy.
    • Highlights the role of ionic imbalance and cellular swelling in nerve pathology.
    • Suggests potential targets for therapeutic interventions in diabetic neuropathy.

    Related Experiment Videos