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Updated: Apr 22, 2026
Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
[Identification of a novel HLA allele HLA-DRB1*09:01:07]
Xiaofeng Li1, Xu Zhang, Kunlian Zhang
1Liaoning Blood Center, Key Laboratory of Blood Safety Research of Liaoning, Key Laboratory of Blood Safety Research of Shenyang, Shenyang, Liaoning 110044, P.R.China. ljp_63@163.com.
Objective:
To identify and confirm a novel HLA allele in a Chinese Han individual.
Methods:
HLA typing was performed by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) for HLA-A, -B and -DRB1 in a registered donor of China Marrow Donor Program(CMDP). Sequencing-based typing (SBT) was carried out to further confirm the novel allele of HLA-DRB1.
Results:
The SSOP result showed HLA-DRB1*09:03,15GEP, but an unusual pattern that could not be defined indicated potential presence of a novel allele. The SBT result showed the novel sequence has 1nt change from its closest allele DRB1*09:01:02 at nt306 where C to T(codon 73 GCC to GCT) resulting in no amino acid change. 73A was not changed.
Conclusion:
A novel HLA allele, HLA-DRB1*09:01:07, has been identified and named officially by WHO Nomenclature Committee for Factors of the HLA System.
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