[Combined GnRH analogs/hMG/hCG treatment]

Ovarian stimulation with human menopausal gonadotropins after Gn-RH-analogue induced pituitary desensitization has been shown to optimize the follicular maturation. This is mostly due to the avoidance of irregular endogenous LG-reactions which occur during hMG-therapy in about one third of the treatment cycles. In several studies using Buserelin or Decapeptyl as Gn-RH-analogue 282 patients were treated for in vitro fertilization, gamete intrafallopian transfer or as part of an "in vivo" therapy. Pregnancy rates were significantly improved in all groups: HMG/hCG therapy resulted in a pregnancy rate of 17% per patient whereas by the combined therapy in 25% of the patients a pregnancy was achieved.