Effect of cyclodextrin complexation on phenylpropanoids' solubility and antioxidant activity
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Updated: Apr 22, 2026

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
Published on: August 23, 2024
Miriana Kfoury1, David Landy2, Lizette Auezova3
1Bioactive Molecules Research Group, Doctoral School of Science and Technology, Department of Chemistry and Biochemistry, Faculty of Sciences-2, Lebanese University, Lebanon ; Univ Lille Nord de France, F-59000 Lille, France ; ULCO, UCEIV, F-59140 Dunkerque, France.
Abstract:
The complexation abilities of five cyclodextrins (CDs) with seven phenylpropanoids (PPs) were evaluated by UV-visible spectroscopy, phase solubility studies and molecular modeling. Formation constants (K f), complexation efficiency (CE), PP:CD molar ratio, increase in formulation bulk and complexation energy were assessed. All complexes exhibited a 1:1 stoichiometry but their stability was influenced by the nature and the position of the phenyl ring substituents. A relationship between the intrinsic solubility of guests (S 0) and the solubilizing potential of CD was proposed. Molecular modeling was used to investigate the complementarities between host and guest. Finally, the antioxidant activity of encapsulated PPs was evaluated by scavenging of the stable DPPH radical.
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