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Aortic elastic properties predict occult coronary artery disease: a multidetector row computed tomography study
Emre Gürel1, Kursat Tigen, Tansu Karaahmet
1Ordu State Hospital, Ordu, Turkey. emregurelctf@yahoo.com.
Kardiologia Polska
|October 10, 2014
Summary
Aortic stiffness index (ASI) can predict occult coronary artery disease (CAD) noninvasively. A cut-off value of 3.42 for ASI may help identify individuals for preventive strategies against atherosclerosis.
Area of Science:
- Cardiovascular Imaging and Diagnostics
- Vascular Biology and Atherosclerosis Research
Background:
- Multidetector row computed tomography (MDCT) detects coronary atherosclerotic plaques but has limitations.
- Safer, practical methods are needed to predict occult coronary artery disease (CAD).
Purpose of the Study:
- To evaluate the predictive value of aortic elastic properties for occult CAD detected by MDCT.
- To assess if aortic stiffness can identify subclinical atherosclerosis.
Main Methods:
- Forty subjects with normal coronary arteries underwent MDCT and were categorized into no CAD and occult CAD groups.
- A control group with evident CAD was included.
- Aortic stiffness index (ASI), distensibility, and strain were calculated using echocardiography and blood pressure measurements.
Main Results:
- ASI, aortic distensibility, and strain differed significantly between no CAD, occult CAD, and evident CAD groups.
- Receiver operating characteristics analysis showed an area under the curve of 0.80 for ASI in distinguishing occult CAD from no CAD.
- An ASI cut-off value of 3.42 predicted occult CAD with 78% sensitivity and 63% specificity.
Conclusions:
- Aortic stiffness measurement, specifically ASI, is a safe, non-radiographic method for assessing aortic stiffness.
- ASI may be useful for predicting subclinical atherosclerosis in clinical practice.
- An ASI cut-off of 3.42 can guide preventive strategies to reduce atherosclerosis progression.
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