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Association between chronic kidney disease and thoracic aortic atherosclerosis detected using transesophageal

Yoshiki Matsumura1, Kenichi Sugioka1, Suwako Fujita1

  • 1Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.

Atherosclerosis
|October 10, 2014
PubMed

Insights

Chronic kidney disease (CKD) is linked to a higher prevalence of complex aortic plaques, particularly in the descending thoracic aorta. This association highlights a significant cardiovascular risk in CKD patients.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Atherosclerosis Research

Background:

  • Accelerated atherosclerosis is common in patients with chronic kidney disease (CKD).
  • Thoracic aortic plaques represent a significant marker of cardiovascular risk.

Purpose of the Study:

  • To investigate the association between CKD and the presence of thoracic aortic plaques.
  • To differentiate plaque presence in the proximal and distal thoracic aorta in relation to CKD.

Main Methods:

  • Transesophageal echocardiography (TEE) was used to assess aortic plaques in 297 patients.
  • CKD was defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m².
  • Multivariate analysis adjusted for traditional atherosclerotic risk factors.

Main Results:

  • Patients with CKD exhibited a significantly higher incidence of any plaques (85% vs. 47%) and complex plaques (42% vs. 17%) compared to those without CKD (P < 0.001).
  • Univariate analysis showed CKD associated with complex plaques in both the distal thoracic aorta (DTA) and proximal thoracic aorta (PTA).
  • Multivariate analysis revealed CKD was significantly associated with complex plaques in the DTA (P < 0.05) but not the PTA.

Conclusions:

  • CKD is associated with complex aortic plaques.
  • The association between CKD and complex aortic plaques is more pronounced in the DTA than the PTA.
Abstract

Keywords:
AortaAtherosclerosisEchocardiographyKidney

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